Animal Models And Clinical Trials - 1158 Words

(WY Mak et. Al, 2014) discusses the concerns of the fact that many drugs that are successful in animal trials are not successful in clinical trials, most specifically, drugs used in cancer treatments. Animal models have been an important factor in the testing of a new drug before it is used in clinical trials, but many drugs that are approved in animal models are not successful in human models. It has been shown that 85% of early clinical trials for novel drugs are not successful and from the remaining 15%, only half are approved for human use. The reason there is a difference in results between animal models and clinical trials have to do with the inability of animals to identically mimic human body functions. An example of a trial that had a difference in results is the TGN1412 trial. TGN1412 was a drug used to treat diseases such as MS, rheumatoid arthritis, and certain cancers. Before used in clinical trials, this drug was first tested in mice. There were no complications shown i n mice that would indicate complications in humans. Humans in clinical trials were given a dose 500 times lower than the dose given to mice and it resulted in catastrophic organ failure. Another study involving IPI-296 in patients with advanced chondrosarcoma was ended early due to the fact that it had no effect shown in clinical trials. When IPI-296 was used on mice, they were shown to have an increase in survival rate. This showed that the effects of the drug on animal models was differentShow MoreRelatedEssay On IRI Challenges In Animals Models785 Words   |  4 PagesIRI challenges in animal Models There are different ways to investigate renal IRI, one of the most common being through the use of animal models in which IRI is induced through renal artery clamping. Various experiments have been carried out using such models to find different methods to ameliorate IRI, which involve the use of many animals. 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